‘The Times They are a Changing’: Exploring Meaningful Change in Health Outcomes Measurement


This webinar will discuss the complementary role of qualitative and quantitative methods for exploring meaningful change in health outcomes measurement including patient-reported outcomes (PRO) and clinician-reported outcomes (ClinRO). 

This webinar will present the advantages and disadvantages of mixed methods approaches, present methods for qualitative exploration, and investigate how qualitative data can be amalgamated with quantitative data to aid interpretation of score changes in clinical trials. An industry perspective will be presented to show how qualitative and quantitative data have been successfully combined to identify responder definitions for clinical trial endpoints.


Recent advances in the field has seen the use of qualitative methodology to explore the score changes that represent meaningful changes for patients and clinicians.

Learning Outcomes/Objectives

After the webinar, the learner will be able to:

  • Understand the benefits of exploring meaningful score change through qualitative and quantitative methods
  • Identify methods for qualitative exploration of meaningful change
  • Consider how to use qualitative and quantitative data to set responder thresholds for clinical trial


  • Helen Kitchen, Senior Consultant & Specialist Team Lead, Clinical Outcomes Assessment, DRG Abacus, Manchester, United Kingdom
  • Cheryl Coon, Principal, Outcometrix, Boston, MA, United States
  • Allison Martin Nguyen, Principal Scientist, CORE- Patient Reported Outcomes & Study Endpoints, Merck, North Wales, Pennsylvania, United States

Thomas Willgoss, PhD, Roche Products Ltd

Organized By:
Psychometrics, Health Preferences Research, QOL in Clinical Practice, and Industry SIGs








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All ISOQOL webinars are planned and presented by ISOQOL member volunteers. Many are the collaborative efforts of one or more Special Interest Groups (SIGs).

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